Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 6/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040353 | 0.93 | GCGR (0.82) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4038180 | 0.93 | GCGR (0.60) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4039285 | 0.83 | GCGR (0.73) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4035540 | 0.80 | GCGR (0.77) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4042947 | 0.79 | GCGR (0.58) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4037339 | 0.77 | GCGR (1.00) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4038176 | 0.76 | GCGR (0.77) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4037178 | 0.76 | GCGR (0.77) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4040281 | 0.75 | GCGR (0.82) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4035262 | 0.75 | GCGR (0.82) | GCGRMAPTTP53ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549655-B1 | SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-01-21 | — | — | EP | disclosed |