Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | JAK1 | P23458 | 4/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036215 | 0.92 | FAAH (0.48) | MAPK1MAPK3JAK2JAK1FAAH | |
| SCHEMBL5186631 | 0.82 | JAK2 (0.47) | MAPK1MAPK3JAK2JAK1P2RX7 | |
| SCHEMBL922525 | 0.81 | MAPK1 (0.74) | MAPK1MAPK3JAK2JAK1 | |
| SCHEMBL4122172 | 0.80 | JAK2 (0.64) | MAPK1MAPK3JAK2JAK1 | |
| SCHEMBL923648 | 0.79 | MAPK1 (0.51) | MAPK1MAPK3JAK2JAK1P2RX7 | |
| SCHEMBL12907359 | 0.77 | NPSR1 (0.54) | MAPK1MAPK3JAK2JAK1P2RX7 | |
| SCHEMBL4039865 | 0.77 | JAK2 (0.67) | MAPK1MAPK3JAK2JAK1 | |
| SCHEMBL4889624 | 0.76 | DYRK1A (0.54) | MAPK1MAPK3JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL923474 | 0.76 | JAK2 (0.65) | MAPK1MAPK3JAK2JAK1 | |
| SCHEMBL4890315 | 0.75 | MAPK1 (0.52) | MAPK1MAPK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765788-B1 | 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES | MERCK PATENT GMBH (DE) | 2009-06-03 | — | — | EP | claimed |
| EP-1765788-B1 | 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES | MERCK PATENT GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |