Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.85 |
| ▸ | KDR | P35968 | 11/20 | 0.69 |
| ▸ | SRC | P12931 | 10/20 | 0.69 |
| ▸ | LCK | P06239 | 2/20 | 0.59 |
| ▸ | YES1 | P07947 | 1/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.59 |
| ▸ | CSK | P41240 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
| ▸ | BRAF | P15056 | 2/20 | 0.59 |
| ▸ | CIT | O14578 | 1/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.59 |
| ▸ | STK17B | O94768 | 1/20 | 0.59 |
| ▸ | STK10 | O94804 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041510 | 0.99 | EGFR (0.84) | EGFRKDRSRCLCKYES1 | |
| SCHEMBL4036399 | 0.96 | EGFR (0.91) | EGFRKDRSRCLCKYES1 | |
| SCHEMBL4207582 | 0.96 | EGFR (0.79) | EGFRKDRSRCLCKYES1 | |
| SCHEMBL4036758 | 0.95 | EGFR (0.90) | EGFRKDRSRCLCKYES1 | |
| SCHEMBL4033873 | 0.93 | EGFR (0.89) | EGFRKDRSRCLCKBRAF | |
| SCHEMBL4034487 | 0.93 | EGFR (0.89) | EGFRKDRSRCLCKYES1 | |
| SCHEMBL4032117 | 0.93 | EGFR (0.78) | EGFRKDRSRCLCKYES1 | |
| SCHEMBL4032976 | 0.93 | EGFR (0.85) | EGFRKDRSRCLCKYES1 | |
| SCHEMBL4034410 | 0.93 | EGFR (0.88) | EGFRKDRSRCLCKYES1 | |
| SCHEMBL4035349 | 0.92 | EGFR (0.85) | EGFRKDRSRCLCKYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |
| CN-1764651-A | Quinazoline derivatives as antitumor agents | ASTRAZENECA AB (SE) | 2006-04-26 | — | — | CN | disclosed |