Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.89 |
| ▸ | SRC | P12931 | 11/20 | 0.66 |
| ▸ | KDR | P35968 | 10/20 | 0.66 |
| ▸ | LCK | P06239 | 2/20 | 0.59 |
| ▸ | YES1 | P07947 | 2/20 | 0.59 |
| ▸ | CSK | P41240 | 2/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | STK10 | O94804 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | HCK | P08631 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033500 | 0.97 | EGFR (0.84) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4042282 | 0.96 | EGFR (0.82) | EGFRSRCKDR | |
| SCHEMBL4035967 | 0.94 | EGFR (1.00) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4036399 | 0.94 | EGFR (0.91) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4036758 | 0.93 | EGFR (0.90) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4035210 | 0.93 | EGFR (0.77) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4041440 | 0.93 | EGFR (0.81) | EGFRSRCKDR | |
| SCHEMBL4034487 | 0.93 | EGFR (0.89) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4034410 | 0.92 | EGFR (0.88) | EGFRSRCKDRLCKYES1 | |
| SCHEMBL4036387 | 0.92 | EGFR (0.93) | EGFRSRCKDRLCKYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |