Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.81 |
| ▸ | SRC | P12931 | 7/20 | 0.60 |
| ▸ | KDR | P35968 | 5/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4202522 | 0.97 | EGFR (0.78) | EGFRSRCKDRERBB2 | |
| SCHEMBL4037323 | 0.95 | EGFR (0.89) | EGFRSRCKDRERBB2 | |
| SCHEMBL4037082 | 0.93 | EGFR (0.82) | EGFRSRCKDR | |
| SCHEMBL4036496 | 0.93 | EGFR (0.82) | EGFRSRCKDRERBB2 | |
| SCHEMBL4037284 | 0.93 | EGFR (0.89) | EGFRSRCKDR | |
| SCHEMBL4031574 | 0.93 | EGFR (0.84) | EGFRSRCKDR | |
| SCHEMBL4031704 | 0.93 | EGFR (0.81) | EGFRSRCKDR | |
| SCHEMBL4032417 | 0.93 | EGFR (0.81) | EGFRSRCKDR | |
| SCHEMBL4036214 | 0.92 | EGFR (0.83) | EGFRSRCKDRERBB2 | |
| SCHEMBL4033873 | 0.91 | EGFR (0.89) | EGFRSRCKDRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |