Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.33 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.32 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TLR2 | O60603 | 1/20 | 0.32 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031894 | 0.86 | NR1I2 (0.43) | MAPK14NR1I2 | |
| SCHEMBL303116 | 0.82 | NR1I2 (0.40) | MAPK14NR1I2 | |
| SCHEMBL4014620 | 0.82 | NPC1 (0.46) | MAPK14NR1I2SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4035781 | 0.80 | MAPK14 (0.51) | MAPK14NR4A3SMN1; SMN2TLR2TLR1 | |
| SCHEMBL4015967 | 0.80 | MAPK14 (0.47) | MAPK14NR4A3SMN1; SMN2ALDH1A1RIPK2 | |
| SCHEMBL302056 | 0.80 | TP53 (0.46) | MAPK14TLR2TLR1ALDH1A1PSEN1 | |
| SCHEMBL13848693 | 0.77 | MAPK14 (0.40) | MAPK14NR1I2RIPK2 | |
| SCHEMBL304557 | 0.77 | MAPK14 (0.39) | MAPK14NR1I2TLR2TLR1ALDH1A1 | |
| SCHEMBL4033769 | 0.77 | MAPK14 (0.41) | MAPK14NR1I2ALDH1A1RIPK2LMNA | |
| SCHEMBL4034420 | 0.76 | MAPK14 (0.40) | MAPK14RIPK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725544-B1 | 3-[4-HETEROCYCLYL-1,2,3-TRIAZOL-1-YL]-N-ARYL-BENZAMIDES AS INHIBITORS OF THE CYTOKINES PRODUCTION FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM PHARMA (US) | 2009-05-27 | — | — | EP | claimed |