Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17888978 | 0.85 | MMP13 (0.58) | PDE5AUSP2KMT2APARP14MMP13 | |
| SCHEMBL403796 | 0.85 | PDE5A (0.64) | POLBRNASEH1ALDH1A1MAPK1HPGD | |
| SCHEMBL13368151 | 0.83 | POLB (0.57) | POLBRNASEH1ALDH1A1MAPK1HPGD | |
| SCHEMBL17888985 | 0.83 | POLB (0.52) | POLBALDH1A1MAPK1KDM4ETDP1 | |
| SCHEMBL17888977 | 0.83 | RNASEH1 (0.55) | POLBRNASEH1KDM4EPDE5ATDP1 | |
| SCHEMBL404601 | 0.82 | KDM4E (0.56) | POLBRNASEH1ALDH1A1MAPK1HPGD | |
| SCHEMBL17888986 | 0.80 | PDE5A (0.72) | POLBALDH1A1KDM4EPDE5ATDP1 | |
| SCHEMBL10054202 | 0.80 | POLB (0.53) | POLBRNASEH1ALDH1A1MAPK1HPGD | |
| SCHEMBL403588 | 0.80 | PDE5A (0.53) | POLBRNASEH1ALDH1A1MAPK1HPGD | |
| SCHEMBL401317 | 0.78 | PDE5A (0.62) | POLBRNASEH1ALDH1A1MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050739-B1 | QUINAZOLINE DERIVATIVE | ASKA PHARM CO LTD (JP) | 2016-07-06 | — | — | EP | claimed |