Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040445 | 0.92 | PGR (0.33) | PDK2PGRKDM4EALDH1A1MAPT | |
| SCHEMBL3145461 | 0.91 | PDK2 (0.34) | PDK2PGRKDM4EALDH1A1MAPT | |
| SCHEMBL3147166 | 0.91 | NPC1 (0.33) | PDK2PGRKDM4EALDH1A1MAPT | |
| SCHEMBL24620697 | 0.88 | APP (0.33) | PDK2MAPT | |
| SCHEMBL16467283 | 0.87 | ACVR1 (0.33) | HTR7HTR1AMAOBACVR1 | |
| SCHEMBL3151355 | 0.87 | PGR (0.32) | PGR | |
| SCHEMBL25716067 | 0.87 | PDK2 (0.34) | PDK2KDM4EALDH1A1MAPT | |
| SCHEMBL19547563 | 0.87 | MAPT (0.30) | MAPT | |
| SCHEMBL25604440 | 0.87 | APP (0.33) | PDK2MAPT | |
| SCHEMBL10102302 | 0.85 | NPC1 (0.32) | KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966180-B1 | PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2015-02-18 | — | — | EP | claimed |
| US-7527754-B2 | Photochromic indeno-fused naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2009-05-05 | — | — | US | claimed |
| EP-3331581-B1 | MECHANOPHORIC MEDICAL PRODUKT | AESCULAP AG (DE) | 2020-07-08 | — | — | EP | disclosed |
| US-7527754-B2 | Photochromic indeno-fused naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2009-05-05 | — | — | US | disclosed |