Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 13/20 | 0.47 |
| ▸ | KIT | P10721 | 8/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.47 |
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.46 |
| ▸ | AXL | P30530 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12780516 | 1.00 | FLT3 (0.47) | FLT3KITAURKAIRAK4KCNH3 | |
| SCHEMBL12780541 | 0.90 | FLT3 (0.45) | FLT3KITAURKAIRAK4KCNH3 | |
| SCHEMBL4036619 | 0.90 | FLT3 (0.45) | FLT3KITAURKAIRAK4KCNH3 | |
| SCHEMBL4038537 | 0.90 | FLT3 (0.46) | FLT3KITAURKAIRAK4KCNH3 | |
| SCHEMBL12780520 | 0.88 | FLT3 (0.48) | FLT3KITAURKAIRAK4KCNH3 | |
| SCHEMBL4047032 | 0.88 | FLT3 (0.48) | FLT3KITAURKAIRAK4KCNH3 | |
| SCHEMBL12780517 | 0.88 | FLT3 (0.48) | FLT3KITAURKAIRAK4KCNH3 | |
| SCHEMBL4038722 | 0.87 | FLT3 (0.44) | FLT3KITAURKAIRAK4AXL | |
| SCHEMBL12780389 | 0.87 | FLT3 (0.44) | FLT3KITAURKAIRAK4AXL | |
| SCHEMBL12780393 | 0.87 | FLT3 (0.44) | FLT3KITAURKAIRAK4AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |