Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.35 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037934 | 0.89 | GCGR (0.46) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4041950 | 0.87 | MAPT (0.36) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4040360 | 0.84 | GCGR (0.49) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4035541 | 0.84 | GCGR (0.48) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4037340 | 0.81 | GCGR (0.44) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4045354 | 0.79 | GCGR (0.40) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4037348 | 0.77 | GCGR (0.60) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4038176 | 0.77 | GCGR (0.77) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4040885 | 0.76 | GCGR (0.50) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4039156 | 0.76 | GCGR (0.47) | GCGRMAPTNPSR1SAE1UBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549655-B1 | SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-01-21 | — | — | EP | claimed |