Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.38 |
| ▸ | LYN | P07948 | 4/20 | 0.38 |
| ▸ | SRC | P12931 | 3/20 | 0.37 |
| ▸ | HCK | P08631 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038564 | 0.85 | MAPK14 (0.43) | LCKLYNSRCHCKMAPK14 | |
| SCHEMBL4039607 | 0.83 | MAPK14 (0.48) | LCKLYNSRCHCKMAPK14 | |
| SCHEMBL4044845 | 0.78 | LCK (0.36) | LCKLYNSRCHCKMAPK14 | |
| SCHEMBL3593604 | 0.78 | MAPK14 (0.44) | LCKLYNSRCHCKMAPK14 | |
| SCHEMBL4039604 | 0.68 | MAPK14 (0.58) | LCKLYNSRCHCKMAPK14 | |
| SCHEMBL3590268 | 0.68 | BRAF (0.43) | LCKLYNSRCHCKMAPK14 | |
| SCHEMBL9967420 | 0.68 | LCK (0.51) | LCKLYNSRCHCKMAPK14 | |
| SCHEMBL3589592 | 0.67 | BRAF (0.48) | LCKLYNSRCHCKINSR | |
| SCHEMBL3589074 | 0.67 | BRAF (0.42) | LCKLYNSRCHCKMAPK14 | |
| SCHEMBL3591361 | 0.66 | LMNA (0.48) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057146-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-05-13 | — | — | EP | claimed |
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | claimed |
| EP-2057146-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | disclosed |