Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | COMT | P21964 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4800330 | 0.81 | MAPK14 (0.63) | CDK2GSK3BGCGRMAPK14 | |
| SCHEMBL4806075 | 0.81 | MAPK14 (0.46) | KMT2AMAPTCDK2MEN1GSK3B | |
| SCHEMBL8221505 | 0.74 | NOTUM (0.47) | KMT2AMAPTCDK2MEN1 | |
| SCHEMBL14484688 | 0.74 | SCN4A (0.59) | KMT2AMAPTCCNE2CDK4CCND1 | |
| SCHEMBL4806374 | 0.74 | KDR (0.47) | KMT2AMAPTCCNE2CDK4CCND1 | |
| Hydrochloric Acid SCHEMBL30014997 | 0.73 | SCN4A (0.57) | KMT2AMAPTCCNE2CDK4CCND1 | |
| SCHEMBL4049176 | 0.72 | MAPT (0.47) | KMT2AMAPTMEN1MAPK14 | |
| SCHEMBL3949166 | 0.72 | CDK4 (0.53) | KMT2ACCNE2CDK4CCND1CCNE1 | |
| SCHEMBL8212288 | 0.72 | AKT1 (0.53) | KMT2AMAPTCDK2MEN1GSK3B | |
| SCHEMBL8212313 | 0.72 | MAPT (0.45) | KMT2AMAPTCCNE2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023411-A1 | COMPOSITIONS AND METHODS FOR TREATING OR CONTROLLING ANTERIOR- AND POSTERIOR-SEGMENT OPHTHALMIC DISEASES | BAUSCH & LOMB INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |