Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | YAP1 | P46937 | 1/20 | 0.38 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034697 | 0.91 | MEN1 (0.48) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL1577410 | 0.91 | MEN1 (0.48) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL4044757 | 0.91 | MEN1 (0.48) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL4040460 | 0.84 | MEN1 (0.46) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL4040407 | 0.83 | MEN1 (0.47) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL4040713 | 0.83 | MEN1 (0.44) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL4035047 | 0.82 | MEN1 (0.45) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL4037562 | 0.82 | MEN1 (0.45) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL4041492 | 0.82 | MEN1 (0.47) | MEN1KMT2AALDH1A1L3MBTL1MAPT | |
| SCHEMBL4041054 | 0.82 | MEN1 (0.44) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |