Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1577410 | 0.92 | MEN1 (0.48) | MEN1KMT2AL3MBTL1ALDH1A1GAA | |
| SCHEMBL4044757 | 0.92 | MEN1 (0.48) | MEN1KMT2AL3MBTL1ALDH1A1GAA | |
| SCHEMBL4034697 | 0.92 | MEN1 (0.48) | MEN1KMT2AL3MBTL1ALDH1A1GAA | |
| SCHEMBL4041054 | 0.88 | MEN1 (0.44) | MEN1KMT2AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL4039869 | 0.88 | HPGD (0.45) | MEN1KMT2AL3MBTL1ALDH1A1RAB9A | |
| SCHEMBL4039515 | 0.84 | EPHX1 (0.44) | MEN1KMT2AL3MBTL1ALDH1A1RAB9A | |
| SCHEMBL4037807 | 0.84 | CTSD (0.46) | MEN1KMT2AL3MBTL1ALDH1A1RAB9A | |
| SCHEMBL4038833 | 0.84 | MEN1 (0.43) | MEN1KMT2AL3MBTL1ALDH1A1GAA | |
| SCHEMBL4040407 | 0.83 | MEN1 (0.47) | MEN1KMT2AL3MBTL1ALDH1A1GAA | |
| SCHEMBL4040713 | 0.83 | MEN1 (0.44) | MEN1KMT2AL3MBTL1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |