Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 6/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.73 |
| ▸ | CDK1 | P06493 | 4/20 | 0.73 |
| ▸ | KDR | P35968 | 3/20 | 0.73 |
| ▸ | MAP3K8 | P41279 | 3/20 | 0.58 |
| ▸ | CLK2 | P49760 | 6/20 | 0.51 |
| ▸ | CLK3 | P49761 | 6/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.51 |
| ▸ | WNT1 | P04628 | 5/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL5823126 | 0.99 | RET (0.72) | RETERBB2CDK1KDRMAP3K8 | |
| SCHEMBL4043674 | 0.90 | RET (0.73) | RETERBB2CDK1KDRMAP3K8 | |
| SCHEMBL13797846 | 0.90 | CDK1 (0.63) | RETERBB2CDK1KDRMAP3K8 | |
| Diethylamine SCHEMBL5819267 | 0.89 | RET (0.72) | RETERBB2CDK1KDRMAP3K8 | |
| SCHEMBL12370787 | 0.86 | RET (0.58) | RETERBB2CDK1KDRMAP3K8 | |
| SCHEMBL12369814 | 0.85 | MAP3K8 (0.59) | RETERBB2CDK1KDRMAP3K8 | |
| SCHEMBL4035569 | 0.84 | RET (0.52) | RETERBB2CDK1KDRMAP3K8 | |
| SCHEMBL4038630 | 0.84 | RET (0.65) | RETERBB2CDK1KDRMAP3K8 | |
| Ethylamine SCHEMBL5823397 | 0.82 | RET (0.62) | RETERBB2CDK1KDRMAP3K8 | |
| SCHEMBL17563929 | 0.81 | CLK2 (0.55) | RETERBB2CDK1KDRMAP3K8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541367-B2 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-06-02 | — | — | US | disclosed |
| US-7541367-B2 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-06-02 | — | — | US | disclosed |
| US-7541367-B2 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-06-02 | — | — | US | disclosed |
| US-20090048249-A1 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-02-19 | — | — | US | disclosed |
| US-20090048249-A1 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-02-19 | — | — | US | disclosed |
| US-20090048249-A1 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048249-A1 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | PRKDC, PRKACA, ABL1 | RET 222/4885ERBB2 104/4885CDK1 307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.