Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 7/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.45 |
| ▸ | AURKA | O14965 | 3/20 | 0.45 |
| ▸ | KIT | P10721 | 5/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SLC34A1 | Q06495 | 5/20 | 0.36 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043796 | 0.83 | FLT3 (0.61) | FLT3IRAK4AURKAKITJAK2 | |
| SCHEMBL12780440 | 0.81 | FLT3 (0.49) | FLT3IRAK4AURKAKITJAK2 | |
| SCHEMBL4042194 | 0.81 | FLT3 (0.46) | FLT3IRAK4AURKAKITJAK2 | |
| SCHEMBL4040887 | 0.81 | FLT3 (0.44) | FLT3IRAK4AURKAKITJAK2 | |
| SCHEMBL4039328 | 0.80 | FLT3 (0.63) | FLT3IRAK4AURKAKITJAK2 | |
| SCHEMBL4040322 | 0.79 | FLT3 (0.67) | FLT3IRAK4AURKAKITJAK2 | |
| SCHEMBL4043675 | 0.78 | AXL (0.45) | FLT3IRAK4AURKAKITJAK2 | |
| SCHEMBL2086579 | 0.78 | FLT3 (0.48) | FLT3IRAK4AURKAKITJAK2 | |
| SCHEMBL4043938 | 0.76 | AURKA (0.51) | FLT3IRAK4AURKAKITAXL | |
| SCHEMBL13963975 | 0.74 | AXL (0.44) | FLT3IRAK4AURKAKITJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |