Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.73 |
| ▸ | BCHE | P06276 | 5/20 | 0.71 |
| ▸ | ACHE | P22303 | 5/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | TNKS | O95271 | 1/20 | 0.65 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13797866 | 0.95 | MAOB (0.73) | MAOBBCHEACHEMEN1TP53 | |
| SCHEMBL13797869 | 0.90 | MAOB (0.73) | MAOBBCHEACHEMEN1TP53 | |
| SCHEMBL9388140 | 0.90 | MAOB (0.68) | MAOBBCHEACHE | |
| SCHEMBL7372368 | 0.87 | SIGMAR1 (0.72) | TNKS | |
| 4,7-Dimethoxyflavone SCHEMBL3470601 | 0.85 | MAOB (1.00) | MAOBMEN1TP53CYP3A4CYP2C9 | |
| SCHEMBL9391105 | 0.82 | SIGMAR1 (0.72) | MEN1TP53CYP3A4KMT2ATNKS | |
| SCHEMBL4036481 | 0.81 | BCHE (0.90) | BCHEACHE | |
| SCHEMBL4403604 | 0.81 | BCHE (0.62) | MAOBBCHEACHEMEN1TP53 | |
| SCHEMBL7366672 | 0.80 | SIGMAR1 (0.49) | MAOBBCHEACHEKDM4EALDH1A1 | |
| SCHEMBL7656355 | 0.80 | MAOB (0.83) | MAOBMEN1TP53CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547794-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-06-16 | — | — | US | disclosed |
| EP-1615906-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004092154-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-10-28 | — | — | WO | disclosed |
| US-20040198750-A1 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198750-A1 | Compositions useful as inhibitors of protein kinases | MAP3K20, MAP3K6, PACSIN2 | MAOB 3049/4885BCHE 2627/4885ACHE 2871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.