Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5821316 | 0.96 | P2RX7 (0.54) | P2RX7CNR2 | |
| SCHEMBL5433736 | 0.88 | P2RX7 (0.51) | P2RX7 | |
| SCHEMBL5138454 | 0.88 | P2RX7 (0.51) | P2RX7 | |
| SCHEMBL5074755 | 0.88 | P2RX7 (0.73) | P2RX7 | |
| Hydrochloric Acid SCHEMBL5710669 | 0.87 | P2RX7 (0.72) | P2RX7 | |
| SCHEMBL5076164 | 0.84 | P2RX7 (0.69) | P2RX7 | |
| SCHEMBL7082054 | 0.84 | P2RX7 (0.78) | P2RX7 | |
| Hydrochloric Acid SCHEMBL5710707 | 0.83 | P2RX7 (0.68) | P2RX7 | |
| SCHEMBL5710639 | 0.83 | P2RX7 (0.68) | P2RX7 | |
| Hydrochloric Acid SCHEMBL5710527 | 0.83 | P2RX7 (0.67) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007505900-A | — | — | 2007-03-15 | — | — | JP | claimed |
| WO-2006083214-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A P2X7 RECEPTOR ANTAGONIST AND A HMG-COA REDUCTASE INHIBITOR | ASTRAZENECA AB (SE) | 2006-08-10 | — | — | WO | claimed |
| EP-1663224-A1 | A PHARMACEUTICAL COMPOSITION COMPRISING A P2X7 RECEPTOR ANTAGONIST AND A NONSTEROIDAL ANTI INFLAMMATORY DRUG | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | claimed |
| WO-2005025571-A1 | A PHARMACEUTICAL COMPOSITION COMPRISING A P2X7 RECEPTOR ANTAGONIST AND A NONSTEROIDAL ANTI INFLAMMATORY DRUG. | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | claimed |
| WO-2009019503-A2 | P2X7 ANTAGONISTS FOR USE IN THE TREATMENT OF MOOD DISORDERS | ASTRAZENECA AB (SE) | 2009-02-12 | — | — | WO | disclosed |
| EP-1644042-A1 | A PHARMACEUTICAL COMPOSITION CONTAINING A P2X7 RECEPTOR ANTAGONIST AND METHOTREXATE | AstraZeneca AB (SE) | 2006-04-12 | — | — | EP | disclosed |
| EP-1633401-A1 | A PHARMACEUTICAL COMPOSITION COMPRISING A P2X7-RECEPTOR ANTAGONIST AND A TUMOUR NECROSIS FACTOR ALPHA | AstraZeneca AB (SE) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004105796-A1 | A PHARMACEUTICAL COMPOSITION CONTAINING A P2X7 RECEPTOR ANTAGONIST AND METHOTREXATE | ASTRAZENECA AB (SE) | 2004-12-09 | — | — | WO | disclosed |
| WO-2004105798-A1 | A PHARMACEUTICAL COMPOSITION COMPRISING A P2X7-RECEPTOR ANTAGONIST AND A TUMOUR NECROSIS FACTOR α | ASTRAZENECA AB (SE) | 2004-12-09 | — | — | WO | disclosed |