Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 18/20 | 0.40 |
| ▸ | CTSS | P25774 | 14/20 | 0.40 |
| ▸ | CTSL | P07711 | 11/20 | 0.38 |
| ▸ | CTSB | P07858 | 10/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | MMP16 | P51512 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039968 | 0.94 | CTSK (0.41) | CTSKCTSSCTSLCTSBLARS1 | |
| SCHEMBL4040095 | 0.92 | CTSK (0.42) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4042709 | 0.91 | CTSK (0.43) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4041250 | 0.89 | CTSK (0.38) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4044324 | 0.87 | CTSK (0.43) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4040066 | 0.84 | CTSK (0.39) | CTSKCTSSCTSLCTSBLARS1 | |
| SCHEMBL4042265 | 0.84 | CTSK (0.49) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4043172 | 0.83 | CTSK (0.41) | CTSKCTSSCTSLCTSBLARS1 | |
| SCHEMBL4040924 | 0.83 | CTSK (0.45) | CTSKCTSSCTSLCTSB | |
| SCHEMBL6212824 | 0.83 | CTSK (0.39) | CTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |