SCHEMBL4040299

SCHEMBL4040299

CC(=O)On1cnc2cccc(C#N)c21

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 2/20 0.37
MAPT P10636 1/20 0.36
ELANE P08246 1/20 0.35
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
KMT2A Q03164 3/20 0.34
ALDH1A1 P00352 3/20 0.34
KDM4E B2RXH2 2/20 0.34
HTT P42858 1/20 0.34
AR P10275 2/20 0.34
MAPK1 P28482 2/20 0.33
HCRTR1 O43613 1/20 0.33
HCRTR2 O43614 1/20 0.33
USP2 O75604 1/20 0.33
ESR2 Q92731 1/20 0.33
LRRK2 Q5S007 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
FGFR1 P11362 1/20 0.32
NAMPT P43490 1/20 0.32
HPGD P15428 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27645619 0.79 FGFR1 (0.33) MAPTKMT2AALDH1A1KDM4EHTT
SCHEMBL27645618 0.79 CYP2C9 (0.34) NOTUMMAPTKMT2AALDH1A1HTT
SCHEMBL27645569 0.79 PSMB8 (0.37) NOTUMKMT2AALDH1A1MAPK1SMN1; SMN2
SCHEMBL27625200 0.77 POLB (0.33) MAPTKMT2AALDH1A1KDM4EHTT
SCHEMBL27625206 0.76 AR (0.40) NOTUMMAOAMAOBARHPGD
SCHEMBL8931989 0.74 GABRA1 (0.48) MAPTKMT2AALDH1A1KDM4EMAPK1
Water SCHEMBL10742458 0.73 USP5 (0.38) MAPTKMT2ASMN1; SMN2TSHR
SCHEMBL1884001 0.72 KMT2A (0.46) MAPTKMT2AKDM4EHTTSMN1; SMN2
SCHEMBL21486449 0.72 DPP4 (0.45) KMT2AMAPK1USP2FGFR1TSHR
SCHEMBL10727242 0.71 USP5 (0.39) MAPTKMT2ASMN1; SMN2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113631544-A Crystalline forms of (S) -2- (7-cyano-1H-benzimidazol-1-yl) -N- {1- [4- (1-cyano-1-methylethyl) phenyl ] ethyl } acetamide 尼奥迈德研究所 - 研究所尼奥迈德 2021-11-09 CN disclosed
EP-2051967-B1 BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATMENT OF VALLINOID RECEPTOR TRPV1 RELATED DISORDERS NEOMED INST (CA) 2014-12-31 EP disclosed
EP-2051967-A1 BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATMENT OF VALLINOID RECEPTOR TRPV1 RELATED DISORDERS AstraZeneca AB (SE) 2009-04-29 EP disclosed
WO-2008018827-A1 BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATMENT OF VALLINOID RECEPTOR TRPV1 RELATED DISORDERS ASTRAZENECA AB (SE) 2008-02-14 WO disclosed