Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048246 | 0.89 | PDGFRB (0.39) | CHEK1MEN1KMT2ACYP2D6PDGFRB | |
| SCHEMBL4045291 | 0.86 | HRH3 (0.43) | HRH3PLK1CHEK1MEN1KMT2A | |
| SCHEMBL4043029 | 0.84 | HRH3 (0.45) | HRH3CHEK1MEN1KMT2APDGFRB | |
| SCHEMBL4050263 | 0.84 | PDGFRB (0.51) | CHEK1MEN1KMT2APDGFRBKIT | |
| SCHEMBL4045066 | 0.83 | PDGFRB (0.44) | HRH3PLK1CHEK1MEN1KMT2A | |
| SCHEMBL4047919 | 0.82 | HRH3 (0.43) | HRH3PLK1CHEK1MEN1KMT2A | |
| SCHEMBL4046728 | 0.82 | SGMS2 (0.36) | PLK1CHRNB2CHRNA4CHEK1PDGFRB | |
| SCHEMBL4211398 | 0.79 | HRH3 (0.43) | HRH3PLK1CHEK1MEN1KMT2A | |
| SCHEMBL4043059 | 0.79 | CHEK1 (0.45) | HRH3PLK1CHEK1MEN1KMT2A | |
| SCHEMBL4047622 | 0.78 | PDGFRB (0.49) | HRH3CHEK1MEN1KMT2APDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-B1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-01 | — | — | EP | disclosed |
| CN-100396670-C | N-substituted 3-aminobenzene-pyrazoles as PDFG receptor inhibitors, pharmaceutical compositions and uses | JANSSEN PHARMACEUTICA NV (BE) | 2008-06-25 | — | — | CN | disclosed |
| CN-1668601-A | N-substituted tricyclic 3-aminopyrazoles as PDFG receptor inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-14 | — | — | CN | disclosed |