Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.74 |
| ▸ | EGFR | P00533 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.70 |
| ▸ | RAF1 | P04049 | 3/20 | 0.70 |
| ▸ | HTT | P42858 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.64 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1384007 | 0.85 | CCNA2 (0.67) | MKNK1EGFRMAPTMAPK1RAF1 | |
| SCHEMBL923247 | 0.85 | MKNK1 (1.00) | MKNK1EGFRMAPTMAPK1RAF1 | |
| SCHEMBL924123 | 0.84 | MKNK1 (0.77) | MKNK1EGFRMAPTMAPK1RAF1 | |
| SCHEMBL4045792 | 0.83 | MKNK1 (0.76) | MKNK1EGFRMAPTMAPK1RAF1 | |
| SCHEMBL922549 | 0.83 | EGFR (1.00) | MKNK1EGFRMAPTMAPK1RAF1 | |
| SCHEMBL4039669 | 0.82 | MAPK1 (0.95) | MKNK1EGFRMAPTMAPK1RAF1 | |
| SCHEMBL922886 | 0.81 | MAPT (0.50) | MKNK1EGFRMAPTMAPK1RAF1 | |
| SCHEMBL923360 | 0.80 | MKNK1 (0.71) | MKNK1EGFRMAPTMAPK1RAF1 | |
| SCHEMBL4041935 | 0.80 | MKNK1 (1.00) | MKNK1EGFRMAPTMAPK1RAF1 | |
| SCHEMBL923658 | 0.78 | FGFR1 (1.00) | MKNK1EGFRMAPTMAPK1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009104027-A1 | THERAPEUTIC APPLICATION OF TRICICLIC AROMATIC AND SATURATED BENZO(4,5)THIENO-(2,3-D)PYRIMIDINE DERIVATES, AS WELL AS THEIR THERAPEUTICALLY ACCEPTABLE SALTS | VICHEM CHEMIE KUTATÓ KFT (HU) | 2009-08-27 | — | — | WO | claimed |