Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.76 |
| ▸ | EGFR | P00533 | 5/20 | 0.76 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | RAF1 | P04049 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.63 |
| ▸ | KIT | P10721 | 1/20 | 0.63 |
| ▸ | SRC | P12931 | 1/20 | 0.63 |
| ▸ | FLT1 | P17948 | 1/20 | 0.63 |
| ▸ | FLT4 | P35916 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL924123 | 0.87 | MKNK1 (0.77) | MKNK1EGFRFGFR1MAPK1MAPT | |
| SCHEMBL923247 | 0.86 | MKNK1 (1.00) | MKNK1EGFRFGFR1MAPK1MAPT | |
| SCHEMBL922549 | 0.86 | EGFR (1.00) | MKNK1EGFRFGFR1MAPK1MAPT | |
| SCHEMBL4039669 | 0.85 | MAPK1 (0.95) | MKNK1EGFRFGFR1MAPK1MAPT | |
| SCHEMBL938262 | 0.84 | FGFR1 (0.64) | MKNK1EGFRFGFR1MAPK1MAPT | |
| SCHEMBL4041935 | 0.83 | MKNK1 (1.00) | MKNK1EGFRFGFR1MAPK1MAPT | |
| SCHEMBL4040366 | 0.83 | MKNK1 (0.74) | MKNK1EGFRFGFR1MAPK1MAPT | |
| SCHEMBL923360 | 0.83 | MKNK1 (0.71) | MKNK1EGFRFGFR1MAPK1MAPT | |
| SCHEMBL5629074 | 0.80 | FGFR1 (0.67) | MKNK1FGFR1 | |
| SCHEMBL924310 | 0.79 | MAPT (0.69) | MKNK1EGFRFGFR1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009104027-A1 | THERAPEUTIC APPLICATION OF TRICICLIC AROMATIC AND SATURATED BENZO(4,5)THIENO-(2,3-D)PYRIMIDINE DERIVATES, AS WELL AS THEIR THERAPEUTICALLY ACCEPTABLE SALTS | VICHEM CHEMIE KUTATÓ KFT (HU) | 2009-08-27 | — | — | WO | claimed |
| US-9789111-B2 | Casein kinase 1δ (CK 1δ) inhibitors | ELECTROPHORETICS LIMITED (GB) | 2017-10-17 | — | — | US | disclosed |
| US-9763947-B2 | Casein kinase 1delta (CK1delta) inhibitors | ELECTROPHORETICS LIMITED (GB) | 2017-09-19 | — | — | US | disclosed |
| US-9763947-B2 | Casein kinase 1delta (CK1delta) inhibitors | ELECTROPHORETICS LIMITED (GB) | 2017-09-19 | — | — | US | disclosed |
| US-20160354375-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES | ELECTROPHORETICS LIMITED (GB) | 2016-12-08 | — | — | US | disclosed |
| US-20160058745-A1 | CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS | ELECTROPHORETICS LIMITED (GB) | 2016-03-03 | — | — | US | disclosed |
| US-20160058745-A1 | CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS | ELECTROPHORETICS LIMITED (GB) | 2016-03-03 | — | — | US | disclosed |
| EP-2651404-B1 | CASEIN KINASE 1DELTA (CK1DELTA) INHIBITORS | ELECTROPHORETICS LTD (GB) | 2015-10-14 | — | — | EP | disclosed |
| US-20150209368-A1 | CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS | ELECTROPHORETICS LIMITED (GB) | 2015-07-30 | — | — | US | disclosed |
| US-20140018540-A1 | CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS | ELECTROPHORETICS LIMITED | 2014-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140018540-A1 | CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS | CSNK1G1, CSNK1A1, CSNK1D | MKNK1 109/4885EGFR 1704/4885FGFR1 1960/4885 |
| US-20150209368-A1 | CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS | CSNK1A1, CSNK1G1, CSNK1D | MKNK1 101/4885EGFR 1696/4885FGFR1 1841/4885 |
| US-20160354375-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES | CSNK1G1, CSNK1A1, CSNK1D | MKNK1 70/4885EGFR 1834/4885FGFR1 2009/4885 |
| US-20160058745-A1 | CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS | CSNK1A1, CSNK1G1, CSNK1D | MKNK1 101/4885EGFR 1696/4885FGFR1 1841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.