Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 11/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | NPC1 | O15118 | 6/20 | 0.65 |
| ▸ | GAA | P10253 | 5/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | GLA | P06280 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 3/20 | 0.54 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040416 | 1.00 | KCNA5 (0.66) | KCNA5KCNH2MAPTKDM4EALDH1A1 | |
| SCHEMBL13797852 | 1.00 | KCNA5 (0.66) | KCNA5KCNH2MAPTKDM4EALDH1A1 | |
| SCHEMBL13797831 | 0.86 | MAOB (0.56) | KCNA5KCNH2MAPTKDM4EALDH1A1 | |
| SCHEMBL13797833 | 0.84 | MAPT (0.68) | MAPTKDM4EALDH1A1NPC1GAA | |
| SCHEMBL535143 | 0.80 | KCNA5 (1.00) | KCNA5KCNH2MAPTKDM4EALDH1A1 | |
| SCHEMBL5314498 | 0.78 | MAPT (0.65) | KCNA5KCNH2MAPTKDM4EALDH1A1 | |
| SCHEMBL5314496 | 0.78 | MAPT (0.65) | KCNA5KCNH2MAPTKDM4EALDH1A1 | |
| SCHEMBL11733647 | 0.76 | MAOB (0.67) | KCNA5KCNH2MAPTKDM4EALDH1A1 | |
| SCHEMBL13797838 | 0.75 | MAPT (0.51) | KCNA5KCNH2MAPTKDM4EALDH1A1 | |
| SCHEMBL4041393 | 0.75 | MAPT (0.51) | KCNA5KCNH2MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547794-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-06-16 | — | — | US | disclosed |
| EP-1615906-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004092154-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-10-28 | — | — | WO | disclosed |
| US-20040198750-A1 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198750-A1 | Compositions useful as inhibitors of protein kinases | MAP3K20, MAP3K6, PACSIN2 | KCNA5 2411/4885KCNH2 2751/4885MAPT 1295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.