Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 9/20 | 0.47 |
| ▸ | KDM1A | O60341 | 4/20 | 0.47 |
| ▸ | RCOR1 | Q9UKL0 | 4/20 | 0.47 |
| ▸ | FLT3 | P36888 | 4/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 3/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047090 | 0.98 | EHMT2 (0.48) | EHMT2KDM1ARCOR1FLT3AURKA | |
| SCHEMBL12780015 | 0.88 | FLT3 (0.54) | FLT3AURKAJAK2KITIRAK4 | |
| SCHEMBL12780012 | 0.85 | FLT3 (0.56) | FLT3AURKAJAK2KITIRAK4 | |
| SCHEMBL4039088 | 0.83 | FLT3 (0.51) | FLT3AURKAJAK2KITIRAK4 | |
| SCHEMBL4040144 | 0.81 | HRH3 (0.48) | FLT3KITNSD2ACHEPDE5A | |
| SCHEMBL4048046 | 0.80 | ALDH1A1 (0.49) | EHMT2KDM1ARCOR1FLT3AURKA | |
| SCHEMBL4039353 | 0.80 | FLT3 (0.71) | FLT3AURKAJAK2KITIRAK4 | |
| SCHEMBL12779995 | 0.78 | FLT3 (0.57) | FLT3AURKAJAK2KITIRAK4 | |
| SCHEMBL4041990 | 0.77 | FLT3 (0.74) | FLT3AURKAJAK2KITIRAK4 | |
| SCHEMBL4041228 | 0.75 | FLT3 (0.70) | FLT3AURKAJAK2KITIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |