Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 4/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
| ▸ | ILK | Q13418 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 9/20 | 0.43 |
| ▸ | RAF1 | P04049 | 6/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042161 | 0.91 | KIT (0.60) | KITKDRMAP3K20PDGFRBFLT4 | |
| SCHEMBL4037476 | 0.90 | KIT (0.56) | KITKDRMAP3K20PDGFRBFLT4 | |
| SCHEMBL2202908 | 0.89 | KDR (0.72) | KITKDRMAP3K20PDGFRBFLT4 | |
| SCHEMBL4036311 | 0.89 | KIT (0.60) | KITKDRMAP3K20PDGFRBFLT4 | |
| SCHEMBL4037041 | 0.88 | KDR (0.59) | KITKDRMAP3K20PDGFRBFLT4 | |
| SCHEMBL4035661 | 0.85 | KDR (0.80) | KITKDRMAP3K20PDGFRBFLT4 | |
| SCHEMBL4035875 | 0.84 | KDR (0.54) | KITKDRMAP3K20PDGFRBFLT4 | |
| SCHEMBL4037197 | 0.83 | KIT (0.54) | KITKDRMAP3K20PDGFRBFLT4 | |
| SCHEMBL4037725 | 0.83 | KIT (0.55) | KITKDRMAP3K20PDGFRBFLT4 | |
| SCHEMBL4040249 | 0.81 | KIT (0.53) | KITKDRMAP3K20PDGFRBFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228063-B1 | SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | BAYER CORP (US) | 2009-02-11 | — | — | EP | claimed |