Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | FLT4 | P35916 | 1/20 | 0.54 |
| ▸ | ILK | Q13418 | 1/20 | 0.54 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 8/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036311 | 0.86 | KIT (0.60) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4042161 | 0.86 | KIT (0.60) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL2202908 | 0.86 | KDR (0.72) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4037041 | 0.85 | KDR (0.59) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4035151 | 0.84 | KDR (0.75) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4037197 | 0.84 | KIT (0.54) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4040661 | 0.84 | KIT (0.57) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4037725 | 0.83 | KIT (0.55) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4037476 | 0.82 | KIT (0.56) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4040249 | 0.81 | KIT (0.53) | KDRPDGFRBKITFLT4ILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9808456-B2 | Piperazine thiazole derivatives useful in the treatment of tauopathies such as Alzheimer's disease | REMYND NV (BE) | 2017-11-07 | — | — | US | claimed |
| US-20160101102-A1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | REMYND NV (BE) | 2016-04-14 | — | — | US | claimed |
| EP-2744798-B1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | REMYND NV (BE) | 2016-03-30 | — | — | EP | claimed |
| US-9187440-B2 | Piperazine thiazole derivatives useful in the treatment of tauopathies such as alzheimer's disease | REMYND NV (BE) | 2015-11-17 | — | — | US | claimed |
| CN-103649062-B | Be used for the treatment of the piperazine thiazole derivative of TAU pathology as alzheimer's disease | REMYND N.V. (BE) | 2015-10-07 | — | — | CN | claimed |
| US-20140206699-A1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | REMYND NV (BE) | 2014-07-24 | — | — | US | claimed |
| EP-2744798-A1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | reMynd NV (BE) | 2014-06-25 | — | — | EP | claimed |
| CN-103649062-A | Piperazine thiazole derivatives useful in the treatment of tauopathies such as alzheimer's disease | REMYND NV | 2014-03-19 | — | — | CN | claimed |
| WO-2013024168-A1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | REMYND NV (BE) | 2013-02-21 | — | — | WO | claimed |
| EP-1228063-B1 | SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | BAYER CORP (US) | 2009-02-11 | — | — | EP | claimed |
| US-20050019424-A1 | Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives | BAYER HEALTHCARE LLC | 2005-01-27 | — | — | US | claimed |
| CN-1509141-A | Herbicides based on substituted aryl ketones | �ݶ�ũ�����ѧ�ɷݹ�˾ | 2004-06-30 | — | — | CN | claimed |
| CN-1449247-A | Selective herbicides based on arylsulfonylaminocarbonyl triazolinones | BAYER AG (DE) | 2003-10-15 | — | — | CN | claimed |
| CN-1391441-A | Carbamoyl triazolinone based herbicides | BAYER AG (DE) | 2003-01-15 | — | — | CN | claimed |
| US-9808456-B2 | Piperazine thiazole derivatives useful in the treatment of tauopathies such as Alzheimer's disease | REMYND NV (BE) | 2017-11-07 | — | — | US | disclosed |
| US-9808456-B2 | Piperazine thiazole derivatives useful in the treatment of tauopathies such as Alzheimer's disease | REMYND NV (BE) | 2017-11-07 | — | — | US | disclosed |
| US-20160101102-A1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | REMYND NV (BE) | 2016-04-14 | — | — | US | disclosed |
| CN-1102858-A | New variety of drechslera monoceras, weed control compositions containing the same as an effective ingredient and weed control methods using the same | MITSUI TOATSU CHEMICALS (JP) | 1995-05-24 | — | — | CN | disclosed |
| US-4058408-A | Bis-benzoxazolyl-naphthalenes as optical brighteners | CIBA-GEIGY CORPORATION (US) | 1977-11-15 | — | — | US | disclosed |
| US-3993659-A | Bis-benzoxazolyl-naphthalenes as optical brighteners | CIBA-GEIGY CORPORATION (US) | 1976-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160101102-A1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | MAPT, PSEN1, RTN3 | KDR 2945/4885PDGFRB 1602/4885KIT 4829/4885 |
| US-20050019424-A1 | Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives | KDR, FLT4, FLT1 | KDR 1/4885PDGFRB 7/4885KIT 44/4885 |
| US-20140206699-A1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | MAPT, PSEN1, RTN3 | KDR 2945/4885PDGFRB 1602/4885KIT 4829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.