Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | HTT | P42858 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | MMP14 | P50281 | 3/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.64 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8344720 | 0.89 | KDM4E (0.66) | KDM4EMAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL8344949 | 0.88 | KDM4E (0.60) | KDM4EMAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL13300833 | 0.88 | HSP90AA1 (0.60) | KDM4EMAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL6051170 | 0.87 | KDM4E (0.77) | KDM4EMAPTLMNAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4036925 | 0.87 | KDM4E (0.62) | KDM4EMAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL4037106 | 0.85 | PIK3CD (0.66) | KDM4EMAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL4040720 | 0.85 | KDM4E (0.56) | KDM4EMAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL8344674 | 0.85 | KDM4E (0.56) | KDM4EMAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL12747911 | 0.85 | ALOX12 (0.56) | KDM4EMAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL10027196 | 0.82 | KDM4E (0.60) | KDM4EMAPTLMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101611009-A | Quinoline derivatives | CHRONOGEN INC (US) | 2009-12-23 | — | — | CN | claimed |
| EP-2079699-A1 | QUINOLINE DERIVATIVES | Envivo Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | claimed |
| WO-2008014602-A1 | QUINOLINE DERIVATIVES | ENVIVO PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | WO | claimed |
| CN-101611009-A | Quinoline derivatives | CHRONOGEN INC (US) | 2009-12-23 | — | — | CN | disclosed |