Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 2/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039445 | 0.90 | CNR1 (0.42) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4044499 | 0.90 | CNR1 (0.42) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4039455 | 0.89 | KMT2A (0.48) | NPC1RAB9APOLBKMT2AMEN1 | |
| SCHEMBL4044511 | 0.86 | EPHX2 (0.47) | NPC1RAB9APOLBKMT2AMEN1 | |
| SCHEMBL4044809 | 0.84 | NPC1 (0.46) | NPC1RAB9APOLBKMT2AMEN1 | |
| SCHEMBL4040697 | 0.83 | NPC1 (0.44) | NPC1RAB9APOLBKMT2AMEN1 | |
| SCHEMBL4038973 | 0.83 | NPC1 (0.46) | NPC1RAB9APOLBKMT2AMEN1 | |
| SCHEMBL4044888 | 0.83 | KMT2A (0.45) | NPC1RAB9APOLBKMT2AMEN1 | |
| SCHEMBL4041164 | 0.83 | NPC1 (0.42) | NPC1RAB9APOLBKMT2AMEN1 | |
| SCHEMBL4040710 | 0.83 | NPC1 (0.42) | NPC1RAB9APOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |