Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13146325 | 0.90 | EGFR (0.50) | EGFRCHEK1EPHX2KDRSRC | |
| SCHEMBL4043694 | 0.88 | KDM4E (0.49) | CHEK1EPHX2KDRSRCKDM4E | |
| SCHEMBL4043398 | 0.86 | CHEK1 (0.60) | EGFRCHEK1KDRSRCMAPT | |
| SCHEMBL4041498 | 0.84 | EGFR (0.39) | EGFRKDRSRCMAPT | |
| SCHEMBL6202704 | 0.83 | PDGFRB (0.41) | EGFRSRCMAPTGSK3AGSK3B | |
| SCHEMBL4040728 | 0.83 | CHEK1 (0.42) | EGFRCHEK1EPHX2KDM4EUSP2 | |
| SCHEMBL4048781 | 0.81 | PLK1 (0.40) | EGFRCHEK1KDRSRCKDM4E | |
| SCHEMBL4046441 | 0.79 | KDM4E (0.49) | CHEK1EPHX2KDM4EUSP2 | |
| SCHEMBL4045426 | 0.78 | CHEK1 (0.55) | EGFRCHEK1KDRSRC | |
| SCHEMBL4046659 | 0.78 | CHEK1 (0.61) | EGFRCHEK1KDRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |
| EP-1506175-B1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-01 | — | — | EP | disclosed |