Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 12/20 | 0.41 |
| ▸ | PRKCA | P17252 | 9/20 | 0.41 |
| ▸ | ABL1 | P00519 | 8/20 | 0.41 |
| ▸ | SRC | P12931 | 7/20 | 0.41 |
| ▸ | CDK1 | P06493 | 3/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.39 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | TLK1 | Q9UKI8 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041498 | 0.89 | EGFR (0.39) | PDGFRBEGFRPRKCAABL1SRC | |
| SCHEMBL4048781 | 0.89 | PLK1 (0.40) | PDGFRBEGFRPRKCAABL1SRC | |
| SCHEMBL4041506 | 0.83 | EGFR (0.50) | EGFRSRCGSK3AGSK3BMAPT | |
| SCHEMBL4051929 | 0.80 | LMNA (0.36) | PDGFRBMAPTALDH1A1 | |
| SCHEMBL4044208 | 0.78 | PDGFRB (0.52) | PDGFRBEGFRPRKCAABL1SRC | |
| SCHEMBL13145876 | 0.78 | PDGFRB (0.38) | PDGFRBEGFRPRKCAABL1SRC | |
| SCHEMBL4045621 | 0.77 | KDR (0.39) | PDGFRBEGFRABL1SRCPDGFRA | |
| SCHEMBL4043884 | 0.77 | PDGFRB (0.39) | PDGFRBEGFRABL1SRCCDK1 | |
| SCHEMBL4052012 | 0.77 | HIF1A (0.43) | PDGFRBEGFRPRKCAABL1SRC | |
| SCHEMBL4044937 | 0.77 | PDGFRB (0.47) | PDGFRBEGFRPRKCAABL1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | claimed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | claimed |