SCHEMBL4041840

SCHEMBL4041840

CN(C)CCCOCc1cc2c(s1)-c1cc(Cl)c(Cl)cc1Sc1ccccc1-2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.40
RAD52 P43351 1/20 0.40
CYP1A2 P05177 5/20 0.39
CYP2D6 P10635 5/20 0.39
CYP2C19 P33261 5/20 0.39
CYP3A4 P08684 4/20 0.39
MTOR P42345 3/20 0.39
TP53 P04637 3/20 0.39
THPO P40225 3/20 0.39
NFKB1 P19838 2/20 0.39
MAPK1 P28482 2/20 0.39
LMNA P02545 7/20 0.38
KMT2A Q03164 5/20 0.38
MEN1 O00255 4/20 0.38
PMP22 Q01453 3/20 0.38
GMNN O75496 2/20 0.38
HRH3 Q9Y5N1 2/20 0.37
HTR1A P08908 5/20 0.36
DRD2 P14416 5/20 0.36
TDP1 Q9NUW8 4/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4037443 0.99 RAD52 (0.41) SMN1; SMN2RAD52CYP1A2CYP2D6CYP2C19
SCHEMBL4037897 0.94 RAD52 (0.41) SMN1; SMN2RAD52CYP1A2CYP2D6CYP2C19
Hydrochloric Acid SCHEMBL4035920 0.93 RAD52 (0.43) SMN1; SMN2RAD52CYP1A2CYP2D6CYP2C19
SCHEMBL4039594 0.90 MEN1 (0.39) SMN1; SMN2CYP1A2CYP2D6CYP2C19CYP3A4
SCHEMBL4040369 0.90 LMNA (0.48) SMN1; SMN2RAD52CYP1A2CYP2D6CYP2C19
Hydrochloric Acid SCHEMBL4037809 0.89 KMT2A (0.40) SMN1; SMN2RAD52CYP1A2CYP2D6CYP2C19
SCHEMBL4041467 0.89 CYP3A4 (0.50) SMN1; SMN2RAD52CYP1A2CYP2D6CYP2C19
SCHEMBL6335341 0.89 CYP3A4 (0.50) SMN1; SMN2RAD52CYP1A2CYP2D6CYP2C19
Hydrochloric Acid SCHEMBL4041643 0.89 LMNA (0.49) SMN1; SMN2RAD52CYP1A2CYP2D6CYP2C19
SCHEMBL5415706 0.88 KMT2A (0.39) SMN1; SMN2RAD52CYP1A2CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1284977-B1 THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS GLAXOSMITHKLINE ZAGREB (HR) 2009-06-24 EP claimed