Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.79 |
| ▸ | ATR | Q13535 | 6/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043377 | 0.90 | EGFR (0.78) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4045492 | 0.90 | EGFR (0.78) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4044231 | 0.90 | EGFR (0.78) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4040666 | 0.88 | EGFR (1.00) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4045605 | 0.88 | EGFR (0.74) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4041430 | 0.87 | EGFR (0.80) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4045787 | 0.85 | EGFR (0.78) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4039338 | 0.84 | EGFR (0.71) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4045979 | 0.82 | EGFR (0.76) | EGFRATRFGFR1FGFR2FGFR3 | |
| SCHEMBL4049905 | 0.81 | EGFR (0.64) | EGFRATRFGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817302-A4 | PIPERIDINYL PIPERIDINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-07-01 | — | — | EP | claimed |
| EP-1819677-A4 | 8-PHENYL-5,6,7,8-HYDROQUINOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-03-11 | — | — | EP | claimed |
| EP-1817285-A4 | CYCLOALKYL KETO PIPERIDINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-01-21 | — | — | EP | claimed |
| EP-1819677-A2 | 8-PHENYL-5,6,7,8-HYDROQUINOLINE TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2007-08-22 | — | — | EP | claimed |
| EP-1817285-A2 | CYCLOALKYL KETO PIPERIDINE TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2007-08-15 | — | — | EP | claimed |
| EP-1817302-A2 | PIPERIDINYL PIPERIDINE TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2007-08-15 | — | — | EP | claimed |
| WO-2006073589-A2 | CYCLOALKYL KETO PIPERIDINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-07-13 | — | — | WO | claimed |
| WO-2006060346-A2 | 8-PHENYL-5,6,7,8-HYDROQUINOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-06-08 | — | — | WO | claimed |
| WO-2006057921-A2 | PIPERIDINYL PIPERIDINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-06-01 | — | — | WO | claimed |
| EP-1817284-A4 | CYCLOALKYL PIPERIDINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1819676-A4 | 5-PHENYL-5,6,7,8-HYDROQUINOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-04-15 | — | — | EP | disclosed |
| EP-1819677-A4 | 8-PHENYL-5,6,7,8-HYDROQUINOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |
| EP-1819677-A2 | 8-PHENYL-5,6,7,8-HYDROQUINOLINE TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2007-08-22 | — | — | EP | disclosed |
| EP-1819676-A2 | 5-PHENYL-5,6,7,8-HYDROQUINOLINE TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2007-08-22 | — | — | EP | disclosed |
| EP-1817284-A2 | CYCLOALKYL PIPERIDINE TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006060344-A2 | 5-PHENYL-5,6,7,8-HYDROQUINOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-06-08 | — | — | WO | disclosed |
| WO-2006060346-A2 | 8-PHENYL-5,6,7,8-HYDROQUINOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-06-08 | — | — | WO | disclosed |
| WO-2006057977-A2 | CYCLOALKYL PIPERIDINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-06-01 | — | — | WO | disclosed |