Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.78 |
| ▸ | MET | P08581 | 2/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.51 |
| ▸ | ATR | Q13535 | 6/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044231 | 0.93 | EGFR (0.78) | EGFRMETNTRK1FGFR1FGFR2 | |
| SCHEMBL4047605 | 0.90 | EGFR (0.62) | EGFRMETNTRK1FGFR1FGFR2 | |
| SCHEMBL4040666 | 0.88 | EGFR (1.00) | EGFRFGFR1FGFR2FGFR3ATR | |
| SCHEMBL4045565 | 0.85 | EGFR (0.58) | EGFRMETFGFR1FGFR2FGFR3 | |
| SCHEMBL4041919 | 0.85 | EGFR (0.79) | EGFRFGFR1FGFR2FGFR3ATR | |
| SCHEMBL4045492 | 0.84 | EGFR (0.78) | EGFRMETFGFR1FGFR2FGFR3 | |
| SCHEMBL4043377 | 0.84 | EGFR (0.78) | EGFRNTRK1FGFR1FGFR2FGFR3 | |
| SCHEMBL4041430 | 0.84 | EGFR (0.80) | EGFRFGFR1FGFR2FGFR3ATR | |
| SCHEMBL4049905 | 0.84 | EGFR (0.64) | EGFRMETNTRK1FGFR1FGFR2 | |
| SCHEMBL4045605 | 0.84 | EGFR (0.74) | EGFRMETNTRK1FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |