Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.50 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10809983 | 0.89 | ALDH1A1 (0.72) | GAAALDH1A1SMN1; SMN2IMPDH2IMPDH1 | |
| SCHEMBL4199641 | 0.87 | ALDH1A1 (0.57) | GAAALDH1A1SMN1; SMN2IMPDH2IMPDH1 | |
| SCHEMBL30086938 | 0.85 | ALDH1A1 (0.55) | GAAALDH1A1SMN1; SMN2IMPDH2IMPDH1 | |
| SCHEMBL24072565 | 0.84 | TDP1 (0.70) | GAAALDH1A1SMN1; SMN2FAAHMEN1 | |
| SCHEMBL24073972 | 0.84 | TDP1 (0.55) | GAAALDH1A1SMN1; SMN2KMT2ATDP1 | |
| SCHEMBL6154459 | 0.84 | TDP1 (0.45) | GAAALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL10152859 | 0.84 | ALDH1A1 (0.57) | GAAALDH1A1SMN1; SMN2CYP2C9MAPT | |
| SCHEMBL4851624 | 0.84 | ALDH1A1 (0.55) | GAAALDH1A1SMN1; SMN2IMPDH2IMPDH1 | |
| SCHEMBL22502083 | 0.83 | C5 (0.61) | GAAALDH1A1SMN1; SMN2IMPDH2IMPDH1 | |
| SCHEMBL6249473 | 0.83 | TDP1 (0.53) | GAAALDH1A1SMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |