Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.47 |
| ▸ | CTSL | P07711 | 7/20 | 0.36 |
| ▸ | CTSS | P25774 | 6/20 | 0.36 |
| ▸ | CTSB | P07858 | 2/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047203 | 0.93 | CTSK (0.48) | CTSKCTSLCTSSCTSBACE2 | |
| SCHEMBL4047843 | 0.93 | CTSK (0.49) | CTSKCTSLCTSSCTSBACE2 | |
| SCHEMBL4049584 | 0.93 | CTSK (0.51) | CTSKCTSLCTSSCTSBACE2 | |
| SCHEMBL4046903 | 0.90 | CTSK (0.48) | CTSKCTSLCTSSCTSBKMT2A | |
| SCHEMBL4043538 | 0.90 | CTSK (0.49) | CTSKCTSLCTSSCTSBACE2 | |
| SCHEMBL4042461 | 0.90 | CTSK (0.48) | CTSKCTSLCTSSCTSB | |
| SCHEMBL4051840 | 0.90 | CTSK (0.48) | CTSKCTSLCTSSCTSBACE2 | |
| SCHEMBL4042998 | 0.89 | CTSK (0.49) | CTSKCTSLCTSSCTSBKMT2A | |
| SCHEMBL4039890 | 0.89 | CTSK (0.48) | CTSKCTSLCTSSCTSBACE2 | |
| SCHEMBL4047665 | 0.88 | CTSK (0.51) | CTSKCTSLCTSSCTSBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027128-A2 | FUSED HETEROCYLIC COMPOUNDS AND THEIR USE AS MGLUR5 MODULATORS | Astra Zeneca AB (SE) | 2009-02-25 | — | — | EP | claimed |
| WO-2007130825-A2 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MGLUR5 MODULATORS | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | WO | claimed |
| EP-2027129-A2 | FUSED HETEROCYLIC COMPOUNDS AND THEIR USE AS MGLUR5 MODULATORS | AstraZeneca AB (SE) | 2009-02-25 | — | — | EP | disclosed |
| EP-1919901-A1 | SUBSTITUTED PIPERAZINES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007130824-A2 | FUSED HETEROCYLIC COMPOUNDS AND THEIR USE AS MGLUR5 MODULATORS | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | WO | disclosed |
| WO-2007021573-A1 | SUBSTITUTED PIPERAZINES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | WO | disclosed |