Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 17/20 | 0.43 |
| ▸ | BRAF | P15056 | 17/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041203 | 0.93 | JAK3 (0.55) | JAK3IRAK4KITBRAFFLT1 | |
| SCHEMBL4034704 | 0.92 | JAK3 (0.46) | JAK3IRAK4KITBRAFFLT1 | |
| SCHEMBL6542886 | 0.87 | JAK3 (0.51) | JAK3IRAK4KITBRAFFLT1 | |
| SCHEMBL4034865 | 0.86 | IRAK4 (0.53) | JAK3IRAK4KITBRAFFLT1 | |
| SCHEMBL4034820 | 0.85 | JAK3 (0.46) | JAK3IRAK4KITBRAFFLT1 | |
| SCHEMBL4034696 | 0.84 | JAK3 (0.47) | JAK3IRAK4KITBRAFFLT1 | |
| SCHEMBL6612511 | 0.82 | JAK3 (0.53) | JAK3IRAK4KITBRAF | |
| SCHEMBL4042753 | 0.81 | KIT (0.49) | KITBRAF | |
| SCHEMBL6542947 | 0.80 | JAK3 (0.59) | JAK3IRAK4KITBRAFFLT1 | |
| SCHEMBL6792344 | 0.79 | RXFP1 (0.42) | JAK3IRAK4KITBRAFFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392680-B1 | SELECTIVE ANTHRANILAMIDE PYRIDINE AMIDES AS INHIBITORS OF VEGFR-2 AND VEGFR-3 | BAYER SCHERING PHARMA AG (DE) | 2009-07-22 | — | — | EP | disclosed |
| EP-1392680-A2 | SELECTIVE ANTHRANILAMIDE PYRIDINE AMIDES AS INHIBITORS OF VEGFR-2 AND VEGFR-3 | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002090352-A2 | SELECTIVE ANTHRANILAMIDE PYRIDINE AMIDES AS INHIBITORS OF VEGFR-2 AND VEGFR-3 | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-11-14 | — | — | WO | disclosed |