Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.51 |
| ▸ | MAP4K3 | Q8IVH8 | 4/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.48 |
| ▸ | GRK5 | P34947 | 2/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | GRK2 | P25098 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044782 | 0.90 | EGFR (0.61) | EGFRNTRK1FGFR1FGFR2FGFR3 | |
| SCHEMBL4045729 | 0.90 | EGFR (0.60) | EGFRNTRK1FGFR1FGFR2FGFR3 | |
| SCHEMBL4045589 | 0.90 | EGFR (0.56) | EGFRNTRK1FGFR1FGFR2FGFR3 | |
| SCHEMBL4044231 | 0.90 | EGFR (0.78) | EGFRNTRK1FGFR1FGFR2FGFR3 | |
| SCHEMBL4043542 | 0.89 | EGFR (0.59) | EGFRFGFR1FGFR2FGFR3MAP4K3 | |
| SCHEMBL4049905 | 0.87 | EGFR (0.64) | EGFRNTRK1FGFR1FGFR2FGFR3 | |
| SCHEMBL4038019 | 0.87 | EGFR (0.80) | EGFRFGFR1FGFR2FGFR3MET | |
| SCHEMBL4044744 | 0.87 | EGFR (0.56) | EGFRNTRK1FGFR1FGFR2FGFR3 | |
| SCHEMBL4041097 | 0.86 | EGFR (0.47) | EGFRFGFR1FGFR2FGFR3ATR | |
| SCHEMBL4047605 | 0.86 | EGFR (0.62) | EGFRNTRK1FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |