Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | MAP4K3 | Q8IVH8 | 6/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.49 |
| ▸ | MET | P08581 | 7/20 | 0.47 |
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.45 |
| ▸ | AXL | P30530 | 3/20 | 0.45 |
| ▸ | MST1R | Q04912 | 3/20 | 0.45 |
| ▸ | PLK4 | O00444 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | INSR | P06213 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | FES | P07332 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045729 | 0.93 | EGFR (0.60) | EGFRMAP4K3FGFR3FGFR1FGFR2 | |
| SCHEMBL4042032 | 0.87 | EGFR (0.62) | EGFRMAP4K3FGFR3FGFR1FGFR2 | |
| SCHEMBL4043542 | 0.83 | EGFR (0.59) | EGFRMAP4K3FGFR3FGFR1FGFR2 | |
| SCHEMBL4038019 | 0.83 | EGFR (0.80) | EGFRFGFR3FGFR1FGFR2MET | |
| SCHEMBL4052591 | 0.81 | EGFR (0.64) | EGFRMAP4K3FGFR3FGFR1FGFR2 | |
| SCHEMBL4047605 | 0.80 | EGFR (0.62) | EGFRFGFR3FGFR1FGFR2MET | |
| SCHEMBL2682349 | 0.78 | MET (0.59) | MAP4K3METALKNTRK1FLT3 | |
| SCHEMBL4044782 | 0.77 | EGFR (0.61) | EGFRFGFR3FGFR1FGFR2MET | |
| SCHEMBL4045589 | 0.77 | EGFR (0.56) | EGFRMAP4K3FGFR3FGFR1FGFR2 | |
| SCHEMBL4044231 | 0.77 | EGFR (0.78) | EGFRFGFR3FGFR1FGFR2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |