Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.48 |
| ▸ | CTSL | P07711 | 6/20 | 0.38 |
| ▸ | CTSS | P25774 | 5/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044220 | 0.93 | CTSK (0.50) | CTSKCTSLCTSSCTSB | |
| SCHEMBL4051325 | 0.89 | CTSK (0.48) | CTSKCTSLCTSSCTSBMEN1 | |
| SCHEMBL4043145 | 0.89 | CTSK (0.49) | CTSKCTSLCTSSCTSB | |
| SCHEMBL4050266 | 0.89 | CTSK (0.52) | CTSKCTSLCTSSCTSB | |
| SCHEMBL4049584 | 0.88 | CTSK (0.51) | CTSKCTSLCTSSCTSBACE2 | |
| SCHEMBL4046903 | 0.88 | CTSK (0.48) | CTSKCTSLCTSSCTSBMEN1 | |
| SCHEMBL4048584 | 0.88 | CTSK (0.48) | CTSKCTSLCTSSCTSBACE2 | |
| SCHEMBL4045435 | 0.88 | CTSK (0.48) | CTSKCTSLCTSSCTSBMEN1 | |
| SCHEMBL4048088 | 0.88 | CTSK (0.53) | CTSKCTSSCTSB | |
| SCHEMBL4043745 | 0.88 | CTSK (0.63) | CTSKCTSLCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |