Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 6/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 6/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 7/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | UGCG | Q16739 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043069 | 0.77 | GCGR (0.43) | MEN1KMT2AMAPTALDH1A1TP53 | |
| SCHEMBL4037348 | 0.76 | GCGR (0.60) | MEN1KMT2AMAPTALDH1A1TP53 | |
| SCHEMBL6315675 | 0.75 | NPC1 (0.35) | MAPK10MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL4039270 | 0.75 | GCGR (0.54) | GRM1MAPK10MEN1KMT2AMAPT | |
| SCHEMBL4044047 | 0.74 | GCGR (0.51) | MAPTALDH1A1TP53NPSR1 | |
| SCHEMBL4042167 | 0.74 | GCGR (0.49) | MEN1KMT2AMAPTALDH1A1TP53 | |
| SCHEMBL4042323 | 0.73 | GCGR (0.50) | MAPTALDH1A1TP53NPSR1 | |
| SCHEMBL4043997 | 0.72 | GCGR (0.49) | MAPTALDH1A1TP53NPSR1 | |
| SCHEMBL4044279 | 0.72 | GCGR (0.47) | MAPTALDH1A1TP53NPSR1 | |
| SCHEMBL4039828 | 0.72 | GCGR (0.46) | MAPTALDH1A1TP53SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549655-B1 | SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-01-21 | — | — | EP | claimed |