Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | RAB9A | P51151 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | PKM | P14618 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.74 |
| ▸ | BCHE | P06276 | 1/20 | 0.69 |
| ▸ | KRAS | P01116 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.64 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.64 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | MAOB | P27338 | 5/20 | 0.61 |
| ▸ | MAOA | P21397 | 2/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041794 | 1.00 | NPC1 (0.74) | NPC1MAPTRAB9AKDM4EPKM | |
| SCHEMBL4804215 | 0.85 | MAPT (1.00) | NPC1MAPTRAB9AKDM4EPKM | |
| SCHEMBL29870513 | 0.85 | MAPT (1.00) | NPC1MAPTRAB9AKDM4EPKM | |
| SCHEMBL4804208 | 0.85 | MAPT (1.00) | NPC1MAPTRAB9AKDM4EPKM | |
| SCHEMBL4189525 | 0.85 | KDM4E (0.70) | NPC1MAPTRAB9AKDM4EPKM | |
| SCHEMBL4172319 | 0.83 | NPC1 (0.72) | NPC1MAPTRAB9AKDM4EPKM | |
| SCHEMBL9227613 | 0.82 | NPC1 (0.70) | NPC1MAPTRAB9AKDM4EPKM | |
| SCHEMBL9227606 | 0.82 | NPC1 (0.70) | NPC1MAPTRAB9AKDM4EPKM | |
| SCHEMBL8987299 | 0.82 | BCHE (1.00) | MAPTMEN1ALDH1A1KMT2ABCHE | |
| SCHEMBL8987297 | 0.82 | BCHE (1.00) | MAPTMEN1ALDH1A1KMT2ABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1319659-B1 | TRIAZINONES AND MEDICINAL USE THEREOF | EISAI R&D MAN CO LTD (JP) | 2009-03-11 | — | — | EP | disclosed |
| US-20060189622-A1 | Pyridazinone and triazinone compounds and use thereof as pharmaceutical preparations | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2006-08-24 | — | — | US | disclosed |
| US-20030225081-A1 | Pyridazinones and triazinones and medicinal use thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2003-12-04 | — | — | US | disclosed |
| EP-1319659-A1 | PYRIDAZINONES AND TRIAZINONES AND MEDICINAL USE THEREOF | Eisai Co., Ltd. (JP) | 2003-06-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225081-A1 | Pyridazinones and triazinones and medicinal use thereof | GRIK1, GRIK3, GRIK2 | NPC1 2494/4885MAPT 4269/4885RAB9A 4582/4885 |
| US-20060189622-A1 | Pyridazinone and triazinone compounds and use thereof as pharmaceutical preparations | GRIK3, GRIK1, GRIK2 | NPC1 2506/4885MAPT 3873/4885RAB9A 4719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.