Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.37 |
| ▸ | HTR2A | P28223 | 8/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | HTR2B | P41595 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | PNMT | P11086 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048146 | 1.00 | HTR2C (0.37) | HTR2CHTR2ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL4041674 | 0.99 | HTR2C (0.36) | HTR2CHTR2ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL4041669 | 0.99 | HTR2C (0.36) | HTR2CHTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4043439 | 0.87 | HTR2C (0.39) | HTR2CHTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4043058 | 0.87 | HTR2A (0.33) | HTR2CHTR2AHTR2B | |
| SCHEMBL4043443 | 0.87 | HTR2C (0.39) | HTR2CHTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4043061 | 0.87 | HTR2A (0.33) | HTR2CHTR2AHTR2B | |
| SCHEMBL4040347 | 0.86 | HTR2A (0.35) | HTR2CHTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4044867 | 0.86 | HTR2A (0.35) | HTR2CHTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4041086 | 0.78 | HTR2A (0.32) | HTR2CHTR2AHTR2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |
| EP-1370561-B1 | TETRAHYDRO-PYRAZINO[1,2-A]INDOLES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS | HOFFMANN LA ROCHE (CH) | 2009-02-11 | — | — | EP | claimed |
| US-6844345-B2 | Piperazine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2005-01-18 | — | — | US | disclosed |
| US-20020169163-A1 | Piperazine derivatives | HOFFMAN-LA ROCHE INC. | 2002-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020169163-A1 | Piperazine derivatives | GPR119, SLC5A2, DPP4 | HTR2C 158/4885HTR2A 140/4885SLC6A2 323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.