Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 13/20 | 0.43 |
| ▸ | KIT | P10721 | 8/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12780487 | 1.00 | FLT3 (0.43) | FLT3KITIRAK4AURKAEGFR | |
| SCHEMBL12780389 | 0.92 | FLT3 (0.44) | FLT3KITIRAK4AURKAEGFR | |
| SCHEMBL4038722 | 0.92 | FLT3 (0.44) | FLT3KITIRAK4AURKAEGFR | |
| SCHEMBL12780393 | 0.92 | FLT3 (0.44) | FLT3KITIRAK4AURKAEGFR | |
| SCHEMBL12781147 | 0.91 | CDK1 (0.45) | FLT3KITAURKAAXLJAK2 | |
| SCHEMBL12780484 | 0.88 | FLT3 (0.46) | FLT3KITIRAK4AURKAAXL | |
| SCHEMBL4042422 | 0.88 | FLT3 (0.46) | FLT3KITIRAK4AURKAAXL | |
| SCHEMBL12780482 | 0.88 | FLT3 (0.46) | FLT3KITIRAK4AURKAAXL | |
| SCHEMBL4038537 | 0.85 | FLT3 (0.46) | FLT3KITIRAK4AURKAAXL | |
| SCHEMBL12780516 | 0.83 | FLT3 (0.47) | FLT3KITIRAK4AURKAAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |