Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | MAP4K3 | Q8IVH8 | 8/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.43 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035619 | 0.81 | EGFR (0.55) | EGFRMAP4K3FGFR1FGFR2FGFR3 | |
| SCHEMBL4044869 | 0.80 | MAP4K3 (0.56) | EGFRMAP4K3FGFR1FGFR2FGFR3 | |
| SCHEMBL4038019 | 0.79 | EGFR (0.80) | EGFRFGFR1FGFR2FGFR3MET | |
| SCHEMBL4213635 | 0.78 | EGFR (0.71) | EGFR | |
| SCHEMBL4047217 | 0.78 | EGFR (0.73) | EGFRFGFR1FGFR2FGFR3 | |
| SCHEMBL4048973 | 0.77 | EGFR (0.50) | EGFRMAP4K3JAK2ABL1JAK1 | |
| SCHEMBL4038434 | 0.76 | EGFR (0.57) | EGFRMAP4K3JAK2FGFR1FGFR2 | |
| SCHEMBL4042032 | 0.74 | EGFR (0.62) | EGFRMAP4K3JAK2JAK1TYK2 | |
| SCHEMBL4052067 | 0.74 | EGFR (0.55) | EGFRMAP4K3JAK2FGFR1FGFR2 | |
| SCHEMBL4052605 | 0.74 | EGFR (0.55) | EGFRMAP4K3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076558-A1 | COMPOSITION COMPRISING NEOPENTASILANE AND METHOD OF PREPARING SAME | Dow Corning Corporation (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |
| WO-2008051328-A1 | COMPOSITION COMPRISING NEOPENTASILANE AND METHOD OF PREPARING SAME | DOW CORNING CORPORATION (US) | 2008-05-02 | — | — | WO | disclosed |