Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.38 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1577410 | 0.89 | MEN1 (0.48) | RAB9AALDH1A1NPC1MAPTMEN1 | |
| SCHEMBL4034697 | 0.89 | MEN1 (0.48) | RAB9AALDH1A1NPC1MAPTMEN1 | |
| SCHEMBL4044757 | 0.89 | MEN1 (0.48) | RAB9AALDH1A1NPC1MAPTMEN1 | |
| SCHEMBL4035037 | 0.87 | ALDH1A1 (0.50) | RAB9AALDH1A1NPC1MAPTMEN1 | |
| SCHEMBL4040175 | 0.85 | KMT2A (0.50) | RAB9AALDH1A1NPC1MAPTMEN1 | |
| SCHEMBL4044363 | 0.84 | ALDH1A1 (0.41) | RAB9AALDH1A1NPC1MAPTMEN1 | |
| SCHEMBL4039125 | 0.84 | MEN1 (0.42) | RAB9AALDH1A1NPC1MAPTMEN1 | |
| SCHEMBL4040874 | 0.84 | PTPN1 (0.44) | RAB9AALDH1A1NPC1MAPTMEN1 | |
| SCHEMBL4043980 | 0.84 | ALDH1A1 (0.41) | RAB9AALDH1A1NPC1MAPTMEN1 | |
| SCHEMBL4035711 | 0.83 | TSHR (0.42) | RAB9AALDH1A1NPC1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |