Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | LYN | P07948 | 2/20 | 0.38 |
| ▸ | HCK | P08631 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038897 | 0.92 | MAPK14 (0.46) | MAPK14LCKLYNHCKSRC | |
| SCHEMBL4035179 | 0.89 | LCK (0.42) | MAPK14LCKLYNHCKSRC | |
| SCHEMBL3587482 | 0.83 | MAPK14 (0.46) | MAPK14LCKLYNHCKSRC | |
| SCHEMBL3591361 | 0.82 | LMNA (0.48) | MAPK14BRAF | |
| SCHEMBL3596225 | 0.82 | MAPK14 (0.47) | MAPK14LCKLYNHCKSRC | |
| SCHEMBL3598459 | 0.82 | MAPK14 (0.49) | MAPK14BRAF | |
| SCHEMBL9967420 | 0.81 | LCK (0.51) | MAPK14LCKLYNHCKSRC | |
| SCHEMBL4044445 | 0.81 | MAPK14 (0.48) | MAPK14LCKLYNHCKSRC | |
| SCHEMBL27784501 | 0.81 | KDR (0.42) | MAPK14LCKLYNHCKSRC | |
| SCHEMBL9970882 | 0.80 | MAPK14 (0.43) | MAPK14LCKLYNHCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057146-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-05-13 | — | — | EP | claimed |
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | claimed |
| EP-2057146-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | disclosed |