Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 12/20 | 0.58 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.55 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.55 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | TPH1 | P17752 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL401498 | 0.83 | S1PR1 (0.62) | S1PR1S1PR3S1PR5S1PR4ALOX15 | |
| SCHEMBL403521 | 0.82 | S1PR1 (0.58) | S1PR1S1PR3S1PR5S1PR4ALOX15 | |
| SCHEMBL402626 | 0.82 | S1PR1 (0.60) | S1PR1S1PR3S1PR5S1PR4ALOX15 | |
| SCHEMBL27787936 | 0.82 | S1PR1 (0.60) | S1PR1S1PR3S1PR5S1PR4ALOX15 | |
| SCHEMBL10113635 | 0.82 | S1PR1 (0.55) | S1PR1S1PR3S1PR5S1PR4ALOX15 | |
| SCHEMBL404581 | 0.80 | S1PR1 (0.54) | S1PR1S1PR3S1PR5S1PR4ALOX15 | |
| SCHEMBL1845783 | 0.80 | S1PR1 (0.53) | S1PR1S1PR3S1PR5S1PR4ALOX15 | |
| SCHEMBL404759 | 0.80 | S1PR1 (0.58) | S1PR1S1PR3S1PR5S1PR4ALOX15 | |
| SCHEMBL13416529 | 0.76 | S1PR1 (1.00) | S1PR1S1PR3S1PR5S1PR4ALOX15 | |
| SCHEMBL13960100 | 0.76 | S1PR1 (0.80) | S1PR1S1PR3S1PR5S1PR4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101775-B2 | Indole derivatives as S1P1 Receptor | GLAXO GROUP LIMITED (GB) | 2012-01-24 | — | — | US | disclosed |
| EP-2091949-B1 | INDOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2011-05-18 | — | — | EP | disclosed |