Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.68 |
| ▸ | PRKDC | P78527 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4006257 | 0.89 | ATR (0.74) | ATRPRKDCATM | |
| SCHEMBL13138778 | 0.87 | ATR (0.78) | ATRPRKDCATM | |
| SCHEMBL4045227 | 0.83 | ATR (0.68) | ATR | |
| SCHEMBL2484717 | 0.82 | ATR (1.00) | ATRPRKDCATM | |
| SCHEMBL3054972 | 0.81 | ATR (1.00) | ATRPRKDCATM | |
| SCHEMBL13138782 | 0.81 | ATR (0.77) | ATRPRKDCATM | |
| SCHEMBL13942955 | 0.80 | EGFR (0.58) | ATR | |
| SCHEMBL2509897 | 0.79 | ATR (1.00) | ATRPRKDCATM | |
| SCHEMBL3059386 | 0.78 | ATR (0.73) | ATRPRKDCATM | |
| SCHEMBL2487776 | 0.77 | ATR (1.00) | ATRPRKDCATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |