Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.51 |
| ▸ | PDE4A | P27815 | 8/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | IDE | P14735 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049077 | 0.89 | PDE4B (0.63) | PDE4BPDE4APDE4DKDM4EHTT | |
| SCHEMBL4047003 | 0.81 | ALDH1A1 (0.57) | PDE4BPDE4APDE4DKDM4EHTT | |
| SCHEMBL4046383 | 0.81 | PDE4B (0.54) | PDE4BPDE4APDE4DKDM4EHTT | |
| SCHEMBL4053838 | 0.78 | PDE4B (0.77) | PDE4BPDE4APDE4DHTTRAD52 | |
| SCHEMBL4045640 | 0.76 | PDE4B (0.75) | PDE4BPDE4APDE4DRAD52RXFP1 | |
| SCHEMBL4047115 | 0.75 | PDE4B (0.88) | PDE4BPDE4APDE4DRXFP1ADRB2 | |
| SCHEMBL5011337 | 0.74 | PDE4B (0.78) | PDE4BPDE4APDE4DKDM4EHTT | |
| SCHEMBL4047105 | 0.74 | PDE4B (0.52) | PDE4BPDE4APDE4DKDM4EHTT | |
| SCHEMBL4048522 | 0.73 | PDE4B (0.78) | PDE4BPDE4APDE4DKDM4EHTT | |
| SCHEMBL4054593 | 0.73 | POLB (0.49) | PDE4BPDE4APDE4DKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819710-B1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | ALMIRALL LAB (ES) | 2009-03-11 | — | — | EP | disclosed |